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. 2022 May 12;50(22):12601–12620. doi: 10.1093/nar/gkac332

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© The Author(s) 2022. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 6. — Molecular mechanisms involved in the processing of causes and consequences of replication/transcription conflicts. (A) Modulation of the lag phase duration of the strain having 1 rrn operon (rrnC) relative to WT having 7 rrn operons (0%) by different genetic modifications tested in this study (+/-%). (B) Model showing how transition from stationary to growth phase in cells with reduced numbers of rrn operons and recovery from ribosome damaging treatments in cells with full complement of rrn operons, cause crowding and stalling of RNAPs, R-loop formation, replicon stalling and DNA breakage, most probably upon arrival of the next replicon, at the rrn locus. Proteins involved in the processing of causes and consequences of these replication/transcription conflicts are indicated.