Figure 2.

Hierarchical clustering analysis based on the protein compositions of serum samples during a 9-week use of combined oral contraceptive. Hierarchical clustering dendrogram of samples using the Euclidean distance measure (Y-axis) and the Ward clustering algorithm. The analysis shows that samples from the three study groups were mixed at baseline but after 9 weeks of use of the combined oral contraceptive preparations, the serum proteome profile clustered the participants according to preparation. The EE + DNG group in particular showed distinct clustering. The cluster was produced using MetaboAnalyst. DNG, dienogest; EE, ethinylestradiol; EV, estradiol valerate.