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. 2022 Nov 23;38(1):89–102. doi: 10.1093/humrep/deac250

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© The Author(s) 2022. Published by Oxford University Press on behalf of European Society of Human Reproduction and Embryology.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 4. — Pathway and network analyses of changing proteins during EE + DNG use. Pathway analysis of the 10 pathways most affected during 9-week use of ethinylestradiol + dienogest (EE + DNG). Graph shows category scores; ‘threshold’ indicates the minimum significance level (scored as −log(P-value) from Fisher’s exact test, set here to 1.25). A positive z-score (orange bar) predicts activation of the pathway, whereas a negative (blue bar) predicts inhibition. The analysis was performed with QIAGEN Ingenuity Pathway Analysis (IPA) software. The four pathways in bold text are depicted below as networks. FXR, farnesoid X receptor; LXR, liver X receptor; RXR, retinoid X receptor.