Table II.
Defensins against reproductive tract infection.
| Microorganism1 | Female reproduction2 | Male reproduction3 | ||
|---|---|---|---|---|
| Defensin4 | Reference | Defensin4 | Reference | |
| HIV (Human Immunodeficiency Virus) | HNP1, HNP2, HNP3, HD5 and HD6 | (Klotman et al., 2008; Levinson et al., 2009; Pellett Madan et al., 2015) | α-defensin | (Hirbod et al., 2014; Prodger et al., 2014) |
| HBD1, HBD2 and HBD3 | (Ricci et al., 2009; Aguilar-Jiménez et al., 2011; Jiang et al., 2012; Hughes et al., 2016; Jais et al., 2016; Zupin et al., 2019b) | HBD2 and HBD3 | (Kreuter et al., 2009) | |
| θ-defensin (DEFT) | (Yang et al., 2005) | θ-defensin | Not reported | |
| HPV (Human Papilloma Virus) | HNP1 and HD5 | (Hubert et al., 2014; Zhao et al., 2015) | α-defensin | Not reported |
| HBD1, HBD2, HBD3 and HBD4 | (Erhart et al., 2011; Abe et al., 2013; Segat et al., 2014; Buckley et al., 2016; Szukiewicz et al., 2016) | HBD2 and HBD3 | (Kreuter et al., 2009) | |
| θ-defensin | Not reported | θ-defensin | Not reported | |
| HSV (Herpes Simplex Virus) | HNP1, HNP2 and HNP3 | (John et al., 2005) | α-defensin | Not reported |
| HBD1 and HBD2 | (Keller et al., 2019; Fichorova et al., 2020) | β-defensin | Not reported | |
| θ-defensin | Not reported | θ-defensin | Not reported | |
| Neisseria gonorrhoeae | HNP1, HNP2, HNP3, HD5 and HD6 | (Wiesenfeld et al., 2002; Klotman et al., 2008) | HNP1, HNP2, HNP3, and HD5 | (Porter et al., 2005) |
| β-defensin | Not reported | β-defensin | Not reported | |
| θ-defensin | Not reported | θ-defensin | Not reported | |
| Chlamydia trachomatis | HNP1, HNP2 and HNP3 | (Wiesenfeld et al., 2002; Wiechuła et al., 2007) | HNP1, HNP2, HNP3, and HD5 | (Porter et al., 2005) |
| HBD1, HBD2, HBD3 and HBD4 | (Wiechuła et al., 2010; Mukura et al., 2017; Noda-Nicolau et al., 2017; Fichorova et al., 2020) | β-defensin | Not reported | |
| θ-defensin | Not reported | θ-defensin | Not reported | |
| Gardnerella vaginalis | HNP1, HNP2, HNP3 and HD5 | (Sawada et al., 2006; Fan et al., 2008; Xu et al., 2008) | α-defensin | Not reported |
| HBD1, HBD2 and HBD3 | (Balu et al., 2002; Valore et al., 2006; Fan et al., 2008; Eade et al., 2012; Jiang et al., 2012; Zaga-Clavellina et al., 2012a; Mitchell et al., 2013; Castro et al., 2018; Fichorova et al., 2020; Noda-Nicolau et al., 2021) | β-defensin | Not reported | |
| θ-defensin | Not reported | θ-defensin | Not reported | |
| Escherichia coli | α-defensin | Not reported | Recombinant defensin-21 | (Biswas et al., 2015) |
| HBD1, HBD2 and HBD3 | (Garcia-Lopez et al., 2010; Ghartey et al., 2012; Suff et al., 2020) | DEFB118 and DEFB114 | (Yenugu et al., 2004; Hou et al., 2021) (Yu et al., 2013) | |
| cBD-1, cBD-2, and cBD-3 | (Sang et al., 2005) | |||
| rBD-1, rBD-2, rBD-22, and rBD-42 | (Palladino et al., 2003; Diao et al., 2011; Xin et al., 2015) | |||
| mBin1b | (Li et al., 2001; Fei et al., 2012) | |||
| Candida | α-defensin | Not reported | α-defensin | Not reported |
| HBD1, HBD2 and HBD3 | (Pivarcsi et al., 2005; Wiechuła et al., 2010; Zaga-Clavellina et al., 2012b; Fichorova et al., 2020; Kotani et al., 2020; Miró et al., 2021) | DEFB114 | (Yu et al., 2013) | |
| mBD-1 | (Miró et al., 2017) | |||
| θ-defensin | Not reported | θ-defensin | Not reported | |
| Ureaplasma | α-defensin | Not reported | α-defensin | Not reported |
| HBD3 | (Tantengco et al., 2021) | β-defensin | Not reported | |
| θ-defensin | Not reported | θ-defensin | Not reported | |
| Trichomonas vaginalis | HNP1, HNP2 and HNP3 | (Wiesenfeld et al., 2002) | α-defensin | Not reported |
| HBD2 | (Fichorova et al., 2015) | β-defensin | Not reported | |
| θ-defensin | Not reported | θ-defensin | Not reported | |
The different colors summarize different defensins. The yellow is for α-defensins, the blue is for β-defensins and the green is for θ-defensin.
Microorganism associated with male and female reproductive tract infections.
Research on defensins related to female reproduction, germ-related cell lines, germ-related tissues, germ-related organs and germ-related secretions were included.
Research on defensins-related male reproduction, germ-related cell lines, germ-related tissues, germ-related organs and germ-related secretions were included.
Human neutrophil defensins (HNP), human α-defensin 5 (HD5), human α-defensin 6 (HD6), human β-defensin (HBD), canine β-defensin (cBD), rat β-defensin (rBD), mouse β-defensin (mBD), mBin1b: a β-defensin gene identified in the mouse epididymis.