Table 1.
Clinical and demographic features of the study population
| Active CD | |||||
|---|---|---|---|---|---|
| Patient No. | Calprotectin (µg/g) | Disease Location (Montreal Classification)a | Age at Stool Collection (y) | Age at Diagnosis (y) | Treatment |
| 1 | 903 | L3 | 63 | 31 | Humira 80 mg/wk |
| 2 | 73 | L3 | 14 | 13 | Pentasa 2 g/d |
| 3 | >1800 | L2 | 61 | 24 | No treatment |
| 4 | 240 | L1 | 58 | 14 | Inflectra 10 mg/kg every 6 wk + Salazopyrin |
| 5 | 101 | L3 | 53 | 20 | Simponi 50 mg/month |
| 6 | >1800 | L1 | 20 | 17 | No treatment |
| 7 | >1800 | L1 | 18 | 16 | No treatment |
| 8 | 753 | L1 + L4 | 26 | 23 | Stelara 90 mg/month |
| 9 | 283 | L3 | 28 | 28 | Idacio 40 mg every 2 wk + Solupred 40 mg/d |
| 10 | >1800 | L1 | 14 | 13 | Entocort 9 mg/d |
| 11 | 852 | L1 | 9 | 9 | Methotrexate 7.5 mg/wk + Hydrocortisone 12.5 mg/m²/d |
| 12 | 1371 | L2 | 9 | 8 | Infliximab 10 mg/kg every 4 wk + Imurel 75 mg/d |
| 13 | 1482 | L2 | 15 | 12 | Humira 40 mg every 2 wk |
| 14 | >1800 | L3 | 14 | 10 | Stelara 45 mg every 4 wk + Methotrexate 10 mg/wk |
| 15 | 124 | L1 | 30 | 20 | Entyvio 300 mg every 4 wk + Solupred 30 mg/d |
| 16 | 1641 | L2 | 18 | 10 | Humira 40 mg every 2 wk |
| 17 | >1800 | L3 + L4 | 16 | 16 | Humira 40 mg every 2 wk + Solupred 10 mg/d |
| 18 | 40 | L1 + L4 | 10 | 10 | Humira 40 mg every 2 wk + Imurel 75 mg/d + Hydrocortisone 10 mg/d |
| Inactive CD | |||||
| 19 | 31 | L3 | 34 | 20 | No treatment |
| 20 | >1800 | L1 | 29 | 18 | Inflectra 10 mg/kg every 6 wk |
| 21 | 214 | L1 + L4 | 20 | 18 | Humira 80 mg every 2 wk |
| 22 | <30 | L3 | 31 | 21 | Inflectra 10 mg/kg every 8 wk |
| 23 | <30 | L1 | 54 | 36 | No treatment |
| 24 | <30 | L1 | 40 | 37 | Imurel 200 mg/d |
| 25 | <30 | L1 | 34 | 24 | Idacio 40 mg every 2 wk |
| 26 | <30 | L1 | 27 | 22 | Inflectra 5 mg/kg every 8 wk |
| 27 | 352 | L3 | 35 | 15 | Stelara 90 mg every 8 wk |
| 28 | 309 | L3 | 64 | 24 | Entyvio 300 mg every 4 wk |
| 29 | >1800 | L4 | 60 | 45 | Inflectra 10 mg/kg every 8 wk + Imurel 175 mg/d |
| 30 | 35 | L1 | 24 | 18 | Inflectra 10 mg/kg every 6 wk |
| 31 | <30 | L2 | 43 | 32 | Imurel 125 mg/d + Pentasa 2 g/d |
| 32 | 479 | L3 | 18 | 10 | Entyvio 5 mg/kg every 6 wk + Pentasa 4 g/d |
| 33 | >1800 | L1 | 14 | 14 | Humira 40 mg every 2 wk |
| 34 | 66 | L3 + L4 | 57 | 32 | Imurel 200 mg/d + Remsima 120 mg every 2 wk |
| 35 | 44 | L3 | 29 | 22 | Entyvio 300 mg every 4 wk |
| 36 | 1221 | L1 | 12 | 12 | Pentasa 3 g/d |
| 37 | 86 | L1 | 26 | 19 | No treatment |
| 38 | <30 | L3 | 68 | 46 | Pentasa 2 g/d + Inexium 40 mg/d |
| 39 | 430 | L1 | 25 | 16 | Infliximab 10 mg/kg every 6 wk |
| 40 | 444 | L3 | 36 | 20 | Stelara 90 mg every 8 wk + Infliximab 5 mg/kg every 8 wk |
| 41 | <30 | L1 | 44 | 28 | Entyvio 300 mg every 4 wk |
| 42 | 48 | L3 | 40 | 23 | Entyvio 300 mg every 8 wk |
| 43 | 128 | L3 + L4 | 17 | 13 | Inflectra 10 mg/kg every 4 wk + Imurel 150 mg/d |
| 44 | 939 | L1 | 36 | 33 | Cimzia 400 mg/month + Questran 1 bag/d |
| 45 | 368 | L1 | 36 | 20 | Entyvio 300 mg every 8 wk |
| 46 | 93 | L3 + L4 | 17 | 10 | Humira 80 mg every 2 wk + Pentasa 2 g/d |
| 47 | 1002 | L3 | 13 | 9 | Humira 80 mg/wk |
| 48 | 690 | L3 | 13 | 12 | Infliximab 10 mg/kg every 4 wk + Imurel 100 mg/d |
| Unrelated IBD | |||||
| Patient No. | Calprotectin (µg/g) | Symptoms/Diseases | Age at Stool Collection (y) | Age at Diagnosis (y) | Treatment |
| 49 | <30 | Chronic abdominal pains | 11 | 7 | Forlax 2 bags/d |
| 50 | <30 | Abdominal pains | 8 | 2 | No treatment |
| 51 | 37 | Irritable bowel syndrome | 32 | 31 | Gluten-free diet |
| 52 | 346 | Abdominal pains | 61 | 58 | Low Fodmap diet |
| 53 | <30 | Functional colopathy | 39 | Many years | Low Fodmap diet |
| 54 | 92 | Abdominal pains + mucus and bloody stools + constipation | 16 | 11 | Forlax 1 bag/d |
| 55 | 324 | Cystic fibrosis + gastroesophageal reflux + constipation | 11 | 0 | Forlax when needed |
| 56 | 350 | Cystic fibrosis | 2 | 0 | No treatment |
| 57 | 311 | Mucus and bloody stools + gastroesophageal reflux | 0 | 0 | No treatment |
| 58 | 35 | Chronic abdominal pains + transit disorders | 24 | 24 | Debridat |
| 59 | 70 | Functional colopathy | 34 | 29 | Pantoprazole 20 mg/d + Bedelix |
| 60 | <30 | Dyspepsia + chronic epigastralgia | 48 | 48 | No treatment |
aL1: ileal; L2: colonic; L3: ileocolonic; L4: upper gastrointestinal tract.
Abbreviations: CD, Crohn’s disease; IBD, inflammatory bowel disease.