Table 3.
Time × Group Analyses, Excluding Patients Who Developed Brain Metastases
| Time Point | Factor | Hippocampus | Gray Matter | NAWM | WMHI | Accelerated Aging | Memory Recall | |
|---|---|---|---|---|---|---|---|---|
| Baseline, 4-month follow-up | Time | F | 59.388 | 63.217 | 19.764 | 38.739 | 121.964 | 16.067 |
| P | <.001 | <.001 | <.001 | <.001 | <.001 | <.001 | ||
| Group | F | .242 | 5.720 | 1.436 | 4.210 | 5.110 | .957 | |
| P | .624 | .019 | .234 | .043 | .026 | .331 | ||
| Time × Group | F | 4.989 | 0.248 | 0.977 | 0.466 | 0.001 | 2.810 | |
| P | .028 | .619 | .326 | .496 | .982 | .097 | ||
| HA-PCI | n | 54 | 54 | 54 | 52 | 55 | 52 | |
| PCI | n | 40 | 40 | 40 | 38 | 40 | 37 | |
| Baseline, 4- and 12-month follow-up | Time | F | 102.982 | 15.691 | 67.998 | 16.615 | 39.498 | 2.603 |
| P | <.001 | <.001 | <.001 | <.001 | <.001 | .087 | ||
| Group | F | 1.867 | 1.780 | 0.012 | 2.096 | 3.618 | .054 | |
| P | .178 | .189 | .915 | .154 | .063 | .817 | ||
| Time × Group | F | 15.593 | 2.162 | 1.926 | 1.059 | 0.261 | 1.190 | |
| P | <.001 | .127 | .157 | .355 | .772 | .315 | ||
| HA-PCI | n | 25 | 25 | 25 | 26 | 26 | 23 | |
| PCI | n | 24 | 24 | 24 | 22 | 24 | 20 |
Abbreviations: HA-PCI, hippocampal avoidance prophylactic cranial radiation; NAWM, normal-appearing white matter; WMHI, white matter hyperintensities.
Significant P values are displayed in bold.