Table 3.

Immunotherapy Clinical Trials for Progressive IDH-mutant Glioma

Strategy	Registry no.	Institution	Immunotherapy	Phase	Treatment regimen	Status
Vaccine	NCT02193347	Duke University Medical Center	PEPIDH1M	I	PEPIDH1M ± RT + TMZ	Active, not recruiting
Vaccine + ICI	NCT03893903	German Cancer Research Center	IDH1-vac +  anti-PD-L1	I	IDH1 vaccine ± avelumab	Recruiting
ICI	NCT03991832	University Health Network, Toronto	Anti-PD-L1	II	Durvalumab + olaparib	Recruiting
ICI	NCT03925246	Hôpitaux de Paris	Anti-PD-1	II	Nivolumab	Active, not recruiting
ICI + IDHi	NCT04056910	University of Pittsburgh Medical Center	Anti-PD-1	II	Nivolumab + ivosidenib	Recruiting
ICI + RT	NCT02968940	NYU Langone Health	Anti-PD-L1	II	Avelumab + HFRT	Completed
ICI	NCT03718767	National Institutes of Health Clinical Center	Anti-PD-1	II	Nivolumab	Recruiting
ICI	NCT03557359	Columbia University Medical Center	Anti-PD-1	II	Nivolumab	Recruiting