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. 2022 Oct 27;51(D1):D466–D478. doi: 10.1093/nar/gkac937

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© The Author(s) 2022. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 2. — The phylogenetic tree of Pfam 4HBT assemblies. There are two different D2 tetramers (colored in green and red in the tree respectively), one hexamer in D3 symmetry (colored in orange), all of which contain the cluster 1 C2 dimer (side-to-side and head-to-tail, α-helices on one side and β-sheet on the other side, colored in blue) in 88 CFs and 72 UniProts. The tetramer in green branches is formed by α-helical interfaces while the tetramer in red branches is connected by β-sheets. The hexamer is composed of three cluster 1 dimers. The sequence files for UniProt and assemblies can be downloaded from ProtCAD website (http://dunbrack2.fccc.edu/ProtCAD/Results/PfamArchClusterInfo.aspx?GroupId=2822).