Table 4.
(Co-)pathology burden per brain region
| (Co-)pathology score | All donors | FTLD-TDP | FTLD-tau | FTLD-FUS |
|---|---|---|---|---|
| Prefrontal Aβ (0–3) | 0 (0–2.75) | 2 (0–3)a | 0 (0–1.5)b | 0 (0–0) |
| Prefrontal TDP (0–3) | 1 (0–2) | 2 (1–2.25)a,c | 0 (0–0)b | 0 (0–0)b |
| Temporal Aβ (0–3) | 0 (0–1) | 1 (0–2)a | 0 (0–0)b | 0 (0–0) |
| Temporal tau (0–3) | 1 (0–3) | 0 (0–1)a | 3 (2–3)b,c | 1 (0–1)a |
| Temporal TDP (0–3) | 0 (0–2) | 2 (1–2.5)a,c | 0 (0–0)b | 0 (0–0)b |
| Precentral tau (0–3) | 0 (0–2) | 0 (0–0)a | 2 (1–2)b,c | 0 (0–0)a |
| Precentral TDP (0–3) | 0 (0–2) | 2 (1–2)a,c | 0 (0–0)b | 0 (0–0)b |
| Parietal tau (0–3) | 0 (0–2) | 0 (0–0)a | 2 (2–3)b,c | 0 (0–1)a |
| Parietal TDP (0–3) | 0 (0–2) | 2 (1–3)a,c | 0 (0–0)b | 0 (0–0)b |
| Occipital TDP (0–3) | 0 (0–1) | 0.5 (0–1)a,c | 0 (0–0)b | 0 (0–0)b |
| Cingulum Aβ (0–3) | 0 (0–2) | 2 (0–3)a | 0 (0–0)b | 0 (0–0) |
| Cingulum TDP (0–3) | 0 (0–2.75) | 2.5 (2–3)a,c | 0 (0–0)b | 0 (0–0)b |
| Dentate gyrus Aβ (0–3) | 0 (0–0) | 0 (0–0) | 0 (0–0) | 0 (0–0) |
| Dentate gyrus TDP (0–3) | 0.5 (0–1) | 1 (1–2)a,c | 0 (0–0)b | 0 (0–0)b |
| CA4 Aβ (0–3) | 0 (0–0) | 0 (0–0) | 0 (0–0) | 0 (0–0) |
| CA4 TDP (0–3) | 0 (0–1) | 0 (0–1)a,c | 0 (0–0)b | 0 (0–0)b |
| CA3 tau (0–3) | 1 (0–1.75) | 0 (0–1)a | 2 (1–2)b,c | 0 (0–1)a |
| CA3 TDP (0–3) | 0 (0–0) | 0 (0–1)a | 0 (0–0)b | 0 (0–0) |
| CA2 TDP (0–3) | 0 (0–1) | 1 (0–1)a,c | 0 (0–0)b | 0 (0–0)b |
| CA1 Aβ (0–3) | 0 (0–1) | 0 (0–2) | 0 (0–0) | 0 (0–0) |
| CA1 TDP (0–3) | 0 (0–1) | 1 (0.75–2)a,c | 0 (0–0)b | 0 (0–0)b |
| Subiculum Aβ (0–3) | 0 (0–1) | 0 (0–2)a | 0 (0–0)b | 0 (0–0) |
| Subiculum tau (0–3) | 1 (0–3) | 1 (0–1)a | 3 (2–3)b,c | 0 (0–0)a |
| Parahippocampal tau (0–3) | 2 (1–3) | 1 (0–2)a | 3 (2–3)b,c | 0 (0–0)a |
| Amygdala TDP (0–3) | 1 (0 -2) | 2 (1–3)a,c | 0 (0–0)b | 0 (0–0)b |
| Amygdala αsyn (0–1) | 0 (0–0) | 0 (0–0) | 0 (0–0) | 0 (0–0) |
| Thalamus tau (0–3) | 1 (0–1) | 0 (0–0)a | 1.5 (1–2)b,c | 0 (0–1)a |
| Thalamus TDP (0–3) | 0 (0–1) | 1 (0–1)a,c | 0 (0–0)b | 0 (0–0)b |
| Subthalamus Aβ (0–3) | 0 (0–0) | 0 (0–0) | 0 (0–0) | 0 (0–0) |
| Subthalamus TDP (0–3) | 0 (0–0) | 0 (0–1)a,c | 0 (0–0)b | 0 (0–0)b |
| Insula Aβ (0–3) | 0 (0–2) | 1 (0–2)a | 0 (0–0)b | 0 (0–0) |
| Sub nigra tau (0–3) | 1 (0–2) | 0 (0–1)a | 2 (2–2.5)b,c | 0 (0–0)a |
| Sub nigra TDP (0–3) | 0 (0–1) | 1 (0–1.5)a,c | 0 (0–0)b | 0 (0–0)b |
| Sub nigra FUS (0–3) | 0 (0–0) | 0 (0–0)c | 0 (0–0)c | 2 (1.25–2.75)a,b |
| Sub nigra αsyn (0–1) | 0 (0–0) | 0 (0–0) | 0 (0–0) | 0 (0–0.25) |
| L coeruleus tau (0–3) | 1 (0–2) | 0 (0–1)a | 2 (2–3)b,c | 1 (1–1)a |
| M oblongata TDP (0–3) | 0 (0–1) | 1 (0–1)a,c | 0 (0–0)b | 0 (0–0)b |
Values are expressed as median ± IQR. Between-groups comparisons were assessed with Kruskal-Wallis one-way ANOVA and pairwise comparisons with Bonferroni correction.
Significant (P < 0.05) difference with FTLD-tau.
Significant (P < 0.05) difference with FTLD-TDP.
Significant (P < 0.05) difference with FTLD-FUS.