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. 2022 Dec 8;51(D1):D384–D388. doi: 10.1093/nar/gkac1096

Table 2.

The largest domain family hierarchies created or updated since CDD release v3.17

Root Models Name
cd14964 592 seven-transmembrane G protein-coupled receptor superfamily
cd00590 586 RNA recognition motif (RRM) superfamily
cd13968 585 Catalytic domain of the Protein Kinase superfamily
cd00162 417 RING finger (Really Interesting New Gene) domain and U-box domain superfamily
cd00174 328 Src Homology 3 domain superfamily
cd00900 327 Pleckstrin homology-like domain
cd00196 311 Beta-grasp ubiquitin-like fold
cd00096 291 Immunoglobulin domain
cd01165 242 BTB/POZ domain superfamily
cd00648 239 Type 2 periplasmic binding fold superfamily
cd15489 221 PHD finger superfamily
cd00083 202 basic Helix Loop Helix (bHLH) domain superfamily
cd01391 191 Type 1 periplasmic binding fold superfamily
cd06174 185 Major Facilitator Superfamily
cd14494 171 Cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
cd17912 170 N-terminal helicase domain of the DEAD-box helicase superfamily
cd08368 159 LIM domain superfamily
cd00014 158 calponin homology (CH) domain superfamily
cd00194 157 UBA domain-like superfamily
cd00105 153 K homology (KH) RNA-binding domain, type I

The table lists the root node of each hierarchy, the number of models in the hierarchy (including the root node and intermediate nodes if present), and the name of the protein domain (super) family.