Table 2.

Median histological active and chronic inflammation, fibrosis and smooth muscle hypertrophy scores using semiquantitative scoring system described by Chen et al. [1], including by individual bowel wall histological layer, from resected pediatric strictured ileal segments (n=18)

Histological layer	Median	Interquartile range
Mucosa
Active inflammation (0–5)	3.0	1.8–5.6
Chronic inflammation (0–12)	5.2	4.0–6.0
Fibrosis (0–3)	0	0–0.5
Smooth muscle hypertrophy (0–3)	1.7	0.5–2.4
Submucosa
Active inflammation (0–9)	0	0–0.6
Chronic inflammation (0–9)	4.3	3.2–5.0
Fibrosis (0–3)	1.3	0.2–2.0
Smooth muscle hypertrophy (0–3)	1.5	0.5–2.3
Muscularis propria
Active inflammation (0–9)	0	0–0.3
Chronic inflammation (0–9)	1.8	0.6–3.0
Fibrosis (0–3)	0	0–0.8
Smooth muscle hypertrophy – inner (circular) layer (0–3)	1.0	0.5–2.0
Smooth muscle hypertrophy – outer (longitudinal) layer (0–3)	0.5	0–1.9
Entire bowel wall*
Active inflammation (0–33)	3.0	2.2–6.4
Chronic inflammation (0–30)	10.4	9.2–12.1
Fibrosis (0–9)	2.1	0.4–2.8
Smooth muscle hypertrophy (0–12)	4.9	3.5–5.8

^*Median of summed scores of individual bowel wall histologic layers for each participant