. Author manuscript; available in PMC: 2024 Jan 1.

Published in final edited form as: Neurol Sci. 2022 Sep 17;44(1):149–157. doi: 10.1007/s10072-022-06386-0

Table 4.

Associations of Biomarkers with 5-year Cognitive Decline in the Beaver Dam Offspring Study

	5-year Cognitive Decline
Baseline Biomarker	Model 1^a RR (95% CI)	Model 2^b RR (95% CI)
IL-6 ≥2.28 pg/mL	1.20 (0.88, 1.65)	1.14 (0.83, 1.55)
sVCAM-1 ≥635.4 ng/mL	1.46 (1.07, 2.00)	1.45 (1.06, 1.99)
WBC, per 10³/μL	1.12 (1.03, 1.20)	1.10 (1.02, 1.19)

Note. N=1574. Results are based on Poisson models; CI: confidence interval; IL-6: interleukin-6; RR: relative risk; sVCAM-1: soluble vascular cell adhesion molecule-1; WBC: white blood cell count.

Model 1: Includes IL-6, sVCAM-1, WBC and age and sex.

Model 2: Includes IL-6, sVCAM-1, WBC and age, sex, education, cardiovascular disease, carotid artery plaque, and history of heavy alcohol use.