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. Author manuscript; available in PMC: 2023 Jan 8.
Published in final edited form as: Mol Cell. 2022 Dec 6:S1097-2765(22)01131-5. doi: 10.1016/j.molcel.2022.11.018

Figure 6. Quantification of RIG-I ligands reveals RIG-I signaling to be highly efficient.

Figure 6.

(A and B) IFNB mRNA expression in A549 cells transfected with SLR14 (A) or SeV (B) at 10-fold dilutions for 6 h.

(C–F) IFNB mRNA expression in A549 cells infected with 0.01–100 HA/mL SeV for 3–24 h. Total DI copies/cell were plotted against fold change in IFNB mRNA expression to determine the total number of RNAs required to stimulate an IFN response at 3 h (C), 6 h (D), 12 h (E) and 24 h (F). Data are means of three independent experiments. Error bars indicate standard deviation.