Fig. 1.

Example invocation of vembrane filter. The file ids.txt contains one ID per line and is parsed as a set. In plain English, the filter expression translates to ‘keep all records from chromosome 2 where the quality is at least 30 or the ID is in the set of known IDs, and where at least “pathogenic” or “drug_response” is part of the clinical significance annotations, and where the sum of read depths across all samples that report a homozygous genotype is at least 10’