Fig. 1.

Website view of small molecule annotations in UniProtKB, including cognate ligand binding site annotations—from www.uniprot.org/uniprotkb/P00175/entry. All small molecule annotations are shown in the ‘Function’ section. (A) The ‘Catalytic Activity’ subsection describes enzymatic reactions using Rhea (which is based on ChEBI), while cofactors are described using ChEBI in the ‘Cofactor’ subsection. Standardization of reaction and cofactor descriptions was performed in previous work, and is shown here for completeness. (B) The ‘Features’ subsection displays the available binding site annotations for cognate ligands described using ChEBI, the subject of this work. Each ligand has a link ‘UniProtKB’ to launch searches for other proteins binding this ligand, a link out to ‘ChEBI’, and expandable sections like ‘Publications’ to examine provenance and evidence