Table 2.

Top 10 predictive proteins for Bradycardia

Rank	Symbol	VAPPV	LR	Evidence
1	LYNX1	N/A	N/A	Kessler et al. (2017)
2	HTR3E	N/A	N/A
3	HTR3A	0.307	3.65	Jeggo et al. (2005)
5	HTR3B	0.433	6.39
4	ADRB1	0.274	3.19	Kelley et al., (2018) and Gao et al. (2019)
6	CHRNE	0.385	5.11
8	CHRNA5	0.318	3.83	Riese et al. (2014) and Picciotto and Kenny (2013)
10	CHRNA3	0.218	2.55
7	REN	0.175	2.15	Poirier and Tobe (2014)
9	CYP2D6	0.273	3.18	Meloche et al. (2020) and Sharp et al. (2009)

Note: Proteins in bold have direct causal evidence for ADR.