Table 3.
Top 10 KEGG pathways enriched by the top 50 predictive proteins for Bradycardia
| Rank | Name | P-value | Evidence |
|---|---|---|---|
| 1 | Neuroactive ligand–receptor interaction | 1.1e–05 | Silvani et al. (2016) and Herring et al. (2008) |
| 2 | Serotonergic synapse | 1.3e–05 | Ramage (2001) and N’Diaye et al. (2001) |
| 3 | Cholinergic synapse | 2.3e–05 | Meyer and Sommers (1988) |
| 4 | Nicotine addiction | 2.5e–05 | Persico (1992) |
| 5 | cAMP signaling pathway | 2.8e–05 | Milanesi et al. (2006) |
| 6 | Taste transduction | 3.4e–05 | Horio (2000) |
| 7 | Gastric acid secretion | 4.6e–05 | Cuomo et al. (2006) and Rogers and Hermann (1985) |
| 8 | Calcium signaling pathway | 8.1e–05 | Graudins et al. (2016) |
| 9 | Renin secretion | 9.1e–05 | Adachi et al. (2015) |
| 10 | Adrenergic signaling in cardiomyocytes | 1.2e–04 | Lymperopoulos et al. (2013) |
Note: KEGG pathways in bold have direct causal evidence for ADR.