Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Jan 8;13:389. doi: 10.1038/s41598-022-27348-8

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Nucleocapsid protein shares significant homology with MS-associated proteins. (A) PEPMatch was used to determine the overlap between nucleocapsid protein from SARS-CoV-2 and MS-associated proteins, which were determined using an IEDB query. For comparison, 30 iterations of shuffled-sequence nucleocapsid protein were run through the analysis with the same parameters as the intact nucleocapsid sequence, whose average was then compared to MS-associated proteins. Fisher’s exact or Chi square tests were run on both the 9mer and the 15mer peptides, with up to 2 mismatches for the 9mer peptides and up to 7 mismatches for the 15mer peptides. (B–F) The same analysis was run as in (A) using the specified proteins labeled above each graph from SARS-CoV-2. (G) Shown are the proteins whose peptides significantly overlapped with nucleocapsid across both the 9mer and 15mer groups.