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Evidence of neurodegeneration in the ALS cohort. (A) NFL t-test, ****P < 0.00005, t = 6.039 and (B) pNFH t-test, ***P < 0.0005, t = 3.698 chains were elevated in ALS (n = 56) compared with controls (n = 44). Pearson’s correlation between NFL and pNFH in controls (C) and in ALS (D).
