Table 4.
Distribution of Pathogens by Extended-Spectrum β-Lactamase, Ciprofloxacin, Trimethoprim–Sulfamethoxazole, and Nitrofurantoin Susceptibility—Microbiologic Modified Intent-to-Treat Population
| Susceptibility Category | Sulopenem (N = 517) n (%) |
Ciprofloxacin (N = 554) n (%) |
Total (N = 1071) n (%) |
|---|---|---|---|
| Ciprofloxacin-nonsusceptible | 150 (29.0) | 143 (25.8) | 293 (27.4) |
| β-lactam–nonsusceptible | 330 (63.8) | 345 (62.3) | 675 (63.0) |
| ȃExtended-spectrum β-lactamase–positive | 73 (14.1) | 72 (13.0) | 145 (13.5) |
| ȃOnly amoxicillin/ampicillin–nonsusceptible | 88 (17.0) | 95 (17.1) | 183 (17.1) |
| Trimethoprim–sulfamethoxazole-nonsusceptible | 171 (33.1) | 167 (30.1) | 338 (31.6) |
| Nitrofurantoin-nonsusceptible | 97 (18.8) | 95 (17.1) | 192 (17.9) |
| Nonsusceptible to 3 classes | 65 (12.6) | 51 (9.2) | 116 (10.8) |
| Nonsusceptible to 4 classes | 25 (4.8) | 28 (5.1) | 53 (4.9) |
Patients were considered extended-spectrum β-lactamase–positive if they had a baseline urine specimen positive for at least 1 Enterobacterales with a ceftriaxone minimum inhibitory concentration >1 µg/mL. A pathogen is β-lactam–resistant if it is resistant to at least 1 of the following drugs: sulopenem, cefazolin, ertapenem, meropenem, ampicillin, ceftazidime, ceftriaxone, amoxicillin, imipenem, piperacillin-tazobactam. Nonsusceptible to 3 classes = nonsusceptible to ciprofloxacin, trimethoprim–sulfamethoxazole, and at least 1 β-lactam. Nonsusceptible to 4 classes = nonsusceptible to ciprofloxacin, trimethoprim–sulfamethoxazole, at least 1 β-lactam, and nitrofurantoin.