Table 3.

Case Reports of Tecovirimat Use in Humans With Orthopoxvirus Infections

Case	Age (Years), Sex	Virus	Risk Factor	Site of Infection	Tecovirimat Dose/Frequency	Duration of Tecovirimat	Additional Therapies	Outcome	Reference
1	2, M	Vaccinia	Household contact of a smallpox vaccinee	Skin (eczema vaccinatum)	5 mg/kg × 2 days, 7.5 mg/kg × 2 days, 10 mg/kg × 10 days via nasogastric tube	14 days	Intravenous vaccinia immunoglobulin, cidofovir	Complete resolution	[41]
2	Adult, M	Vaccinia	Acute myeloid leukemia diagnosis after smallpox vaccine	Skin (progressive vaccinia)	400 mg then 800 mg then 1200 mg orally (total 75 g) + 0.5 mL of 1% topical once daily then twice daily	73 days (oral); 68 days (topical)	Intravenous vaccinia immunoglobulin, brincidofovir	Complete resolution (despite increasing EC50 to tecovirimat)	[67]
3	31, F	Cowpox	Exposure to wild rodents	Ocular (keratitis)	400 mg orally twice a day	14 days	Polyclonal gammaglobulin, amniotic membrane transplantations, corneal collagen cross-linking, autologous limbal stem cell transplantation	Complete resolution (after additional therapies)	[82]
4	26, F	Vaccinia	Occupational needlestick	Left index finger	600 mg orally twice a day	14 days	Intravenous vaccinia immunoglobulin	Complete resolution	[83]
5	19, M	Vaccinia	Acute myeloid leukemia diagnosis after smallpox vaccine	Skin, preemptive treatment during chemotherapy	600 mg orally twice a day	62 days	Intravenous vaccinia immunoglobulin	Complete resolution, no recurrence	[84]
6	28, F	Cowpox	Pet cat with lesions	Ocular	Not reported	Prolonged course	Surgical debridement	Complete resolution with sequelae	[85]
7	Middle-aged, M	Mpox	Travel to endemic area	Skin	Not reported	Not reported	Not reported	Complete resolution	[80]
8	30–40, F	Mpox	Exposure to child who traveled to endemic area	Skin	600 mg orally twice a day	14 days	None	Complete resolution	[20]
9	35, F	Vaccinia	Contact with raccoon rabies vaccine bait	Skin	Not reported	14 days	Intravenous vaccinia immunoglobulin	Complete resolution	[86]

Abbreviations: EC₅₀, half-maximal effective concentration; F, female; M, male.