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. 2022 Sep 18;41(28):5517–5536. doi: 10.1002/sim.9580

TABLE 1.

For Scenario 1 with ordered categorical outcome, performance of estimators for β under (a) the null hypothesis β=0 and (b) the alternative β=log(1.5)=0.405 at each interim analysis time (t1,,t4)=(150,195,240,285) days and at the final analysis at tend=330 days

MC mean MC SD Ave MC SE MSE ratio MC mean MC SD Ave MC SE MSE ratio
(a) Null hypothesis
β^𝒯F(t)
β^IPW(t)
t1
0.002 0.294 0.294 1.000 0.004 0.232 0.232 1.603
t2
0.002 0.221 0.221 1.000 0.002 0.189 0.189 1.330
t3
0.003 0.184 0.185 1.000 0.002 0.166 0.164 1.239
t4
0.001 0.162 0.162 1.000 0.001 0.152 0.151 1.139
tend
0.000 0.146 0.146 1.000 0.000 0.147 0.146 0.991
β^AIPW1(t)
β^AIPW2(t)
t1
0.004 0.221 0.221 1.775 0.005 0.203 0.198 2.095
t2
0.002 0.178 0.178 1.534 0.002 0.168 0.165 1.717
t3
0.002 0.156 0.154 1.399 0.002 0.149 0.145 1.542
t4
0.001 0.141 0 .140 1.327 0.001 0.138 0.136 1.380
tend
0.000 0.135 0.135 1.169 0.000 0.135 0.135 1.169
(b) Alternative hypothesis
β^𝒯F(t)
β^IPW(t)
t1
0.408 0.294 0.294 1.000 0.406 0.235 0.235 1.566
t2
0.406 0.220 0.221 1.000 0.406 0.191 0.191 1.336
t3
0.404 0.185 0.185 1.000 0.405 0.167 0.165 1.221
t4
0.406 0.163 0.162 1.000 0.406 0.153 0.152 1.131
tend
0.406 0.147 0.146 1.000 0.406 0.148 0.147 0.985
β^AIPW1(t)
β^AIPW2(t)
t1
0.405 0.224 0.224 1.733 0.406 0.204 0.200 2.078
t2
0.406 0.180 0.180 1.508 0.408 0.169 0.167 1.702
t3
0.405 0.158 0.155 1.378 0.408 0.150 0.147 1.523
t4
0.406 0.142 0.141 1.314 0.407 0.139 0.137 1.373
tend
0.406 0.137 0.136 1.159 0.406 0.137 0.136 1.159

Note: MC mean is the mean of 10 000 Monte Carlo estimates; MC SD is the Monte Carlo SD, Ave MC SE is the mean of Monte Carlo SEs, and MSE ratio is the ratio of Monte Carlo mean square error for β^𝒯F(t) divided by that for the indicated estimator.