Skip to main content
. 2022 Sep 4;45(6):530–542. doi: 10.1111/jvp.13093
Animal# Route C0 CMAX CMAX /dose TMAX AUC0‐Last AUCinf AUC%extrapolated AUCinf/dose T1/2β
(μg/ml) (μg/ml) (μg/ml) / (mg/kg) (mins) (μg*min/ml) (μg*min/ml) (%) (μg*min/ml) / (mg/kg) (mins)
# 10 IV 75.14 58.77 19.59 NA 2140.27 2164.85 1.14 721.62 89.68
# 10 IM NA 9.8 3.27 120 2108.68 2188.97 3.67 729.66 150.42
# 10 TD NA 10.54 1.05 60 1976.91 2143.16 7.76 214.32 320.11
# 11 IV 98.84 83 27.67 NA 3711.68 3766.04 1.44 1255.35 87.63
# 11 IM NA 10.84 3.61 120 2159.13 2206.16 2.13 735.39 130.38
# 11 TD NA 18.49 1.85 120 3263.95 3319.06 1.66 331.91 123.24
# 128 IV 100.04 78.64 26.21 NA 2361.32 2405.84 1.85 801.95 118.69
# 128 IM NA 19.94 6.65 45 3723.33 4095.58 9.09 1365.19 198.48
# 128 TD NA 27.06 2.71 120 5825.76 5956.46 2.19 595.65 135.22
# 14 IV 86.17 81.67 27.22 NA 2905.4 3040.3 4.44 1013.43 194.8
# 14 IM NA 16.68 5.56 60 3413.32 3644.99 6.36 1215 162.21
# 14 TD NA 18.98 1.9 120 3800.27 3858.27 1.5 385.83 114.86
# 160 IV 39.83 47.81 15.94 NA 1698.75 1720.54 1.27 573.51 94.43
# 160 IM NA 6.19 2.06 45 1640.88 NR NR NR 212.43
# 160 TD NA 15.99 1.6 120 3696.12 3758.49 1.66 375.85 108.09
# 169 IV 66.72 53.48 17.83 NA 2278.73 2330.65 2.23 776.88 76.57
# 169 IM NA 9.16 3.05 120 1921.59 1962.55 2.09 654.18 141.96
# 169 TD NA 18.03 1.8 120 3553.86 3675.84 3.32 367.58 169.1
# 175 IV 75.58 67.55 22.52 NA 1935.99 1952.19 0.83 650.73 93.55
# 175 IM NA 13.96 4.65 10 3253.01 4003.15 18.74 1334.38 305.86
# 175 TD NA 34.57 3.46 120 6712.87 6778.97 0.98 677.9 114.55
# 176 IV 49.62 43.82 14.61 NA 1818.59 1837.09 1.01 612.36 85.5
# 176 IM NA 8.07 2.69 45 1621.16 1663.03 2.52 554.34 120.94
# 176 TD NA 17.45 1.75 120 3353.84 3402.66 1.43 340.27 125.33
# 178 IV 117.04 84.03 28.01 NA 2724.4 2766.68 1.53 922.23 112.74
# 178 IM NA 11.81 3.94 120 2577.11 2617.62 1.55 872.54 122.1
# 178 TD NA 26.34 2.63 120 5098.88 5241.25 2.72 524.13 173.13
# 181 IV 90.05 62.28 20.76 NA 2492.46 2513.4 0.83 837.8 63.11
# 181 IM NA 8.36 2.79 20 1596.31 1655.05 3.55 551.68 145.42
# 181 TD NA 17.26 1.73 120 3288.71 3350.07 1.83 335.01 141.77
# 183 IV 47.9 50.74 16.91 NA 1808.47 1848.13 2.15 616.04 144.67
# 183 IM NA 8.87 2.96 120 1926.76 1990.63 3.21 663.54 163.96
# 183 TD NA 18.88 1.89 120 3948.98 4136.55 4.53 413.66 183.12
# 184 IV 75.94 64.19 21.4 NA 2484.7 2669.15 6.91 889.72 290.57
# 184 IM NA 13.23 4.41 60 2570.17 2600.38 1.16 866.79 110.22
# 184 TD NA 14.03 1.4 120 2761.7 2852.83 3.19 285.28 154.05