Animal# | Route | C0 | CMAX | CMAX /dose | TMAX | AUC0‐Last | AUCinf | AUC%extrapolated | AUCinf/dose | T1/2β |
---|---|---|---|---|---|---|---|---|---|---|
(μg/ml) | (μg/ml) | (μg/ml) / (mg/kg) | (mins) | (μg*min/ml) | (μg*min/ml) | (%) | (μg*min/ml) / (mg/kg) | (mins) | ||
# 10 | IV | 75.14 | 58.77 | 19.59 | NA | 2140.27 | 2164.85 | 1.14 | 721.62 | 89.68 |
# 10 | IM | NA | 9.8 | 3.27 | 120 | 2108.68 | 2188.97 | 3.67 | 729.66 | 150.42 |
# 10 | TD | NA | 10.54 | 1.05 | 60 | 1976.91 | 2143.16 | 7.76 | 214.32 | 320.11 |
# 11 | IV | 98.84 | 83 | 27.67 | NA | 3711.68 | 3766.04 | 1.44 | 1255.35 | 87.63 |
# 11 | IM | NA | 10.84 | 3.61 | 120 | 2159.13 | 2206.16 | 2.13 | 735.39 | 130.38 |
# 11 | TD | NA | 18.49 | 1.85 | 120 | 3263.95 | 3319.06 | 1.66 | 331.91 | 123.24 |
# 128 | IV | 100.04 | 78.64 | 26.21 | NA | 2361.32 | 2405.84 | 1.85 | 801.95 | 118.69 |
# 128 | IM | NA | 19.94 | 6.65 | 45 | 3723.33 | 4095.58 | 9.09 | 1365.19 | 198.48 |
# 128 | TD | NA | 27.06 | 2.71 | 120 | 5825.76 | 5956.46 | 2.19 | 595.65 | 135.22 |
# 14 | IV | 86.17 | 81.67 | 27.22 | NA | 2905.4 | 3040.3 | 4.44 | 1013.43 | 194.8 |
# 14 | IM | NA | 16.68 | 5.56 | 60 | 3413.32 | 3644.99 | 6.36 | 1215 | 162.21 |
# 14 | TD | NA | 18.98 | 1.9 | 120 | 3800.27 | 3858.27 | 1.5 | 385.83 | 114.86 |
# 160 | IV | 39.83 | 47.81 | 15.94 | NA | 1698.75 | 1720.54 | 1.27 | 573.51 | 94.43 |
# 160 | IM | NA | 6.19 | 2.06 | 45 | 1640.88 | NR | NR | NR | 212.43 |
# 160 | TD | NA | 15.99 | 1.6 | 120 | 3696.12 | 3758.49 | 1.66 | 375.85 | 108.09 |
# 169 | IV | 66.72 | 53.48 | 17.83 | NA | 2278.73 | 2330.65 | 2.23 | 776.88 | 76.57 |
# 169 | IM | NA | 9.16 | 3.05 | 120 | 1921.59 | 1962.55 | 2.09 | 654.18 | 141.96 |
# 169 | TD | NA | 18.03 | 1.8 | 120 | 3553.86 | 3675.84 | 3.32 | 367.58 | 169.1 |
# 175 | IV | 75.58 | 67.55 | 22.52 | NA | 1935.99 | 1952.19 | 0.83 | 650.73 | 93.55 |
# 175 | IM | NA | 13.96 | 4.65 | 10 | 3253.01 | 4003.15 | 18.74 | 1334.38 | 305.86 |
# 175 | TD | NA | 34.57 | 3.46 | 120 | 6712.87 | 6778.97 | 0.98 | 677.9 | 114.55 |
# 176 | IV | 49.62 | 43.82 | 14.61 | NA | 1818.59 | 1837.09 | 1.01 | 612.36 | 85.5 |
# 176 | IM | NA | 8.07 | 2.69 | 45 | 1621.16 | 1663.03 | 2.52 | 554.34 | 120.94 |
# 176 | TD | NA | 17.45 | 1.75 | 120 | 3353.84 | 3402.66 | 1.43 | 340.27 | 125.33 |
# 178 | IV | 117.04 | 84.03 | 28.01 | NA | 2724.4 | 2766.68 | 1.53 | 922.23 | 112.74 |
# 178 | IM | NA | 11.81 | 3.94 | 120 | 2577.11 | 2617.62 | 1.55 | 872.54 | 122.1 |
# 178 | TD | NA | 26.34 | 2.63 | 120 | 5098.88 | 5241.25 | 2.72 | 524.13 | 173.13 |
# 181 | IV | 90.05 | 62.28 | 20.76 | NA | 2492.46 | 2513.4 | 0.83 | 837.8 | 63.11 |
# 181 | IM | NA | 8.36 | 2.79 | 20 | 1596.31 | 1655.05 | 3.55 | 551.68 | 145.42 |
# 181 | TD | NA | 17.26 | 1.73 | 120 | 3288.71 | 3350.07 | 1.83 | 335.01 | 141.77 |
# 183 | IV | 47.9 | 50.74 | 16.91 | NA | 1808.47 | 1848.13 | 2.15 | 616.04 | 144.67 |
# 183 | IM | NA | 8.87 | 2.96 | 120 | 1926.76 | 1990.63 | 3.21 | 663.54 | 163.96 |
# 183 | TD | NA | 18.88 | 1.89 | 120 | 3948.98 | 4136.55 | 4.53 | 413.66 | 183.12 |
# 184 | IV | 75.94 | 64.19 | 21.4 | NA | 2484.7 | 2669.15 | 6.91 | 889.72 | 290.57 |
# 184 | IM | NA | 13.23 | 4.41 | 60 | 2570.17 | 2600.38 | 1.16 | 866.79 | 110.22 |
# 184 | TD | NA | 14.03 | 1.4 | 120 | 2761.7 | 2852.83 | 3.19 | 285.28 | 154.05 |