FIGURE 5.
Effect of adrenaline (ADr) on (a) spontaneous contractions of human (i) proximal and (ii) distal stomach. (b) ADr‐induced increase in baseline muscle tone (i, ii), amplitude (iii, iv) and frequency (v, vi) of spontaneous contractions of proximal (graphs on left) and distal (right) stomach after 30 min incubation with prazosin (10−7 M), propranolol (10−5 M) or vehicle (dimethyl sulfoxide [DMSO]/water, 0.1% v/v). (c) Comparison of spontaneous contractions and their features in absence (baseline) and presence of [arginine vasopressin (AVP) (10−9 M), ADr (10−8 M) or co‐application of AVP (10−9 M) and ADr (10−8 M). Concentrations of both hormones approximately equivalent to their EC75. *P < 0.05 between data sets for AVP and ADr applied together versus sum of corresponding data for AVP and ADr applied individually. Data are mean ± SEM. n = 5