Table 1.

Summary of tetracoordinated copper(II) complexes with better IC₅₀ values (μM) in different cell lines.

Compound	Metal geometry	Exposure time [h]	Cell lines	IC50 value [μM]	Main feature	Ref.
Cu‐03	Square planar	48	Hep‐G2 BEL‐7402 BEL‐7404 HL‐7702	7.27±0.26 8.66±0.22 11.84±0.31 12.02±0.16	Anticancer activity depends on the binding of the complex with HSA that acts as a drug delivery system	[59]
Cu‐04	Square planar		Hep‐G2 BEL‐7402 BEL‐7404 HL‐7702	5.18±0.19 6.23±0.12 8.92±0.21 12.18±0.15
Cu‐76	Tetrahedral		HCT‐116 MCF‐7	3.26[a] 7.40[a]	The anticancer activity depends on the positive charge of the central metal, the nature of the ligand and the hydrogen bonds	[119]

[a] μg μL⁻¹.