Table 3.

Summary of pentacoordinated copper(II) complexes with ancillary ligands and better IC₅₀ values (μM) in different cell lines.

Compound	Metal geometry	Exposure time [h]	Cell lines	IC50 value [μM]	Main feature	Ref.
Cu‐24	Square pyramidal	72	A‐549 HCT‐116 HeLa MDA‐MB‐231 SH‐SY5Y HASM‐C1 HASM‐C2	1.93±1.56 1.79±0.43 3.13±0.51 3.60±0.37 1.08±0.63 >12.50 >12.50	The anticancer activity depends on the presence of the amino group in the phen co‐ligand	[67]
Cu‐32		48	HUVEC C33A HeLa	3.60±0.05, 2.22±0.17 1.02±0.03	Anticancer activity depends on the phen co‐ligand and its aromaticity	[70]
Cu‐37			HeLa MCF‐7 Hep‐G2	0.46±0.01 0.94±0.06 0.47±0.06	Anticancer activity depends on the presence of the phen ancillary ligand	[72]
Cu‐66		72	A‐2780 MCF‐7	0.75±0.2 2.5±0.6	Anticancer activity depends on the presence of the phen ancillary ligand	[88]
Cu‐67			A‐2780 MCF‐7	0.54±0.2 2.7±0.8
Cu‐68			A‐2780 MCF‐7 HL‐60 HeLa	0.29±0.01 3.5±1.2 1.51±0.37 4.2±0.6