Table 6.

Summary of vanadium(IV) complexes with ancillary ligands and better IC₅₀ values (μM) in different cell lines.

Compound	Metal geometry	Exposure time [h]	Cell lines	IC50 value [μM]	Main feature	Ref.
V‐16	Octahedral	24	A‐2780 PC‐3 MDA‐MB‐231	7.6±1.8 4.6±1.3 30.9±9.0	Anticancer activity depends on the presence of the polypyridyl‐derived ancillary ligand, in this case aminophen and dppz.	[91]
V‐18			A‐2780 PC‐3 MDA‐MB‐231	2.6±0.25 9.5±1.8 16.8±3.2
V‐20			A‐2780 HEK‐293	10.2±5.05 82.8±47.5	Anticancer activity is substituent dependent, brominated derivatives were generally more active than unsubstituted derivatives.	[92]
V‐21			A‐2780 HEK‐293	10.3±3.35 28.8±7.2
V‐26			A‐2780cisR MCF‐7	13.5±4.2 10.4±1.70
V‐27			A‐2780	5.90±1.45
V‐21		72	PC‐3	0.82±0.2
V‐22			PC‐3	0.94±0.35
V‐24			MCF‐7	2.84±1.27
V‐26			A‐2780 MCF‐7	0.73±0.13 2.79±1.32
V‐27			A‐2780	1.35±0.34