Table 10.

Summary of nickel(II) complexes coordinated to O N O ligands with better IC₅₀ values (μM) in different cell lines.

Compound	Metal geometry	Exposure time [h]	Cell lines	IC50 value [μM]	Main feature	Ref.
Ni‐02	Octahedral	24	A‐549 HCT‐116 HL‐60 Caco‐2	31.98±1.6 59.84±3.3 >100 >100	Anticancer activity depends on its high ability to bind to DNA and interact with BSA	[108]
Ni‐11		48	HCT‐116 MCF‐7	11.33[a] 3.42[a]	The anticancer activity depends on the positive charge of the central metal, the nature of the ligand and the hydrogen bonds	[119]

[a] μg μL⁻¹.