Table 13.

Summary of cobalt(II/III) complexes coordinated to O N O ligands with better IC₅₀ values (μM) in different cell lines.

Compound	Metal geometry	Exposure time [h]	Cell lines	IC50 value [μM]	Main feature	Ref.
Co‐02	Octahedral	48	A‐549 MCF‐7	2.46 2.77	Anticancer activity depends on higher DNA binding affinity and higher Kb value	[117]
Co‐03			HeLa A‐549	7.34 20.29	Anticancer activity depends on structural changes in complexes	[118]
Co‐04			HCT‐116 MCF‐7	4.88[a] 3.30[a]	The anticancer activity depends on the positive charge of the central metal, the nature of the ligand and the hydrogen bonds	[119]

[a] μg μL⁻¹.