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Summary of platinum(II) complexes coordinated to O N O ligands with better IC50 values (μM) in different cell lines.
|
Compound |
Metal geometry |
Exposure time [h] |
Cell lines |
IC50 value [μM] |
Main feature |
Ref. |
|---|---|---|---|---|---|---|
|
Pt‐06 |
Square planar |
24[a] |
HeLa |
21.93 |
Anticancer activity depends on the inductive effect and the position of the substituents in the ligand (trans effect). |
[123] |
|
Pt‐10 |
21.05 |
|||||
|
Pt‐11 |
19.14 |
[a] CCK‐8 assay.
