Table 17.

Summary of copper(II) complexes coordinated to O N N ligands with better IC₅₀ values (μM) in different cell lines.

Compound	Metal geometry	Exposure time [h]	Cell lines	IC50 value [μM]	Main feature	Ref.
Cu‐79	Tetrahedral	48	HeLa HepG‐2	7.45±1.36 1.24±0.36	Anticancer activity depends on metal‐ligand synergy (anti‐inflammatory co‐ligand)	[143]
Cu‐80			HeLa HepG‐2	3.70±0.94 2.29±1.25
Cu‐84	Octahedral	72	MDA‐MB‐231 U‐87 PC‐3 HUVEC	8.1 20.7 10.7 28.6	Anticancer activity depends on the functional group NO2 in the Schiff base, facilitating the ROS production and the DNA intercalation	[144]