TABLE 2.

Incidence per million persons for Langerhans cell histiocytosis in England, 2013–2019

	Crude rate (95% CI) a	ASR b (95% CI)	IRR c (95% CI)	p
Age at diagnosis, years
Infants (<1)	11.56 (8.66–15.13)
1–14	4.18 (3.70–4.71)
15–29	0.98 (0.77–1.23)
30–44	1.05 (0.83–1.31)
45–59	1.29 (1.05–1.57)
≥60	0.91 (0.73–1.13)
Children (<15)	4.67 (4.18–5.21)	4.46 (3.99–4.98)	4.35 (3.73–5.07)	<0.001
Adults (≥15)	1.05 (0.94–1.17)	1.06 (0.94–1.18)	1 [Reference]
Overall	1.70 (1.58–1.84)	1.60 (1.48–1.73)
Sex
Female	1.47 (1.31–1.65)	1.41 (1.25–1.59)	1 [Reference]
Male	1.94 (1.75–2.15)	1.79 (1.61–1.98)	1.28 (1.10–1.49)	<0.01
Deprivation quintile
1 – least deprived	1.54 (1.28–1.85)	1.50 (1.31–1.70)	1 [Reference]
2	1.48 (1.22–1.78)	1.45 (1.27–1.65)	0.98 (0.76–1.28)	0.90
3	1.46 (1.20–1.75)	1.41 (1.23–1.60)	0.96 (0.74–1.25)	0.78
4	1.97 (1.67–2.30)	1.84 (1.63–2.06)	1.29 (1.01–1.64)	0.04
5 – most deprived	2.06 (1.75–2.41)	1.86 (1.65–2.09)	1.27 (0.99–1.62)	0.06
Region
North East	1.84 (1.28–2.57)	1.78 (1.23–2.49)	1 [Reference]
North West	1.48 (1.17–1.86)	1.39 (1.09–1.74)	0.79 (0.53–1.18)	0.26
Yorkshire/Humber	1.58 (1.21–2.04)	1.49 (1.13–1.92)	0.85 (0.56–1.29)	0.47
East Midlands	1.39 (1.02–1.86)	1.30 (0.95–1.73)	0.78 (0.50–1.21)	0.28
West Midlands	2.09 (1.67–2.59)	1.98 (1.58–2.45)	1.10 (0.74–1.64)	0.60
East of England	1.43 (1.09–1.83)	1.37 (1.04–1.76)	0.80 (0.53–1.23)	0.34
London	1.59 (1.29–1.94)	1.49 (1.19–1.83)	0.83 (0.56–1.23)	0.35
South East	1.89 (1.56–2.26)	1.78 (1.47–2.13)	1.08 (0.74–1.59)	0.68
South West	2.10 (1.67–2.61)	2.08 (1.65–2.59)	1.21 (0.81–1.82)	0.32

^a 95% CI, 95% confidence interval.

^b ASR, directly age‐standardised incidence.

^c IRR, incidence‐rate ratios, adjusted for children/adults, sex, deprivation, and region.