TABLE 4.
Multivariate analysis of baseline factors associated with overall survival for Langerhans cell histiocytosis in England, 2013–2019
| Hazard ratio (95% CI) a | p | |
|---|---|---|
| Age at diagnosis, years | ||
| Children (<15) | 1 [Reference] | |
| 15–29 | [no death] | |
| 30–44 | 2.32 (0.42–12.93) | 0.34 |
| 45–59 | 11.04 (3.40–35.88) | <0.001 |
| ≥60 | 22.12 (7.10–68.94) | <0.001 |
| Sex | ||
| Female | 1 [Reference] | |
| Male | 2.01 (0.99–4.09) | 0.054 |
| Deprivation quintile | ||
| 1 – least deprived | 1 [Reference] | |
| 2 | 2.45 (0.45–13.24) | 0.30 |
| 3 | 3.13 (0.64–15.35) | 0.16 |
| 4 | 5.36 (1.16–24.87) | 0.03 |
| 5 – most deprived | 3.24 (0.66–15.87) | 0.15 |
| Region | ||
| North East | 1 [Reference] | |
| North West | 0.61 (0.14–2.62) | 0.50 |
| Yorkshire/Humber | 0.63 (0.10–3.94) | 0.62 |
| East Midlands | 0.62 (0.12–3.18) | 0.56 |
| West Midlands | 0.63 (0.14–2.90) | 0.55 |
| East of England | 1.14 (0.25–5.21) | 0.87 |
| London | 0.17 (0.02–1.19) | 0.07 |
| South East | 0.69 (0.16–3.03) | 0.63 |
| South West | 0.61 (0.13–2.78) | 0.52 |
| Ethnicity | ||
| White | 1 [Reference] | |
| Asian | [no death] | |
| Other | 2.38 (0.26–22.07) | 0.44 |
| Unknown | 0.30 (0.04–2.28) | 0.25 |
Abbreviation: CI, confidence interval. a :Adjusted for patient age, sex, deprivation, region, and ethnicity.