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. 2022 Sep 5;61(41):e202207508. doi: 10.1002/anie.202207508

Scheme 1.

Scheme 1

Enzyme‐activatable chemokine conjugates targeting TAMs. Chemokine constructs enter TAMs through CCR2‐mediated endocytosis where they undergo cathepsin‐dependent activation for near‐infrared fluorescence labeling (fluorescent probe chemo‐cat NIR) or doxorubicin‐mediated cell ablation (prodrug chemo‐cat DOX), respectively.