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. 2022 Sep 20;61(45):e202204955. doi: 10.1002/anie.202204955

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© 2022 The Authors. Angewandte Chemie International Edition published by Wiley-VCH GmbH

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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PET radio‐antibiotics evaluated as infection imaging agents and their respective cellular targets. Abbreviated content: G+: Gram‐positive specific; M: Mycobacteria‐specific; B: broad spectrum; FQL: fluoroquinolones; TMP: trimethoprim; INH: isoniazid (including PT70 and PT119); PZA: pyrazinamide; RIF: rifampin; LNZ: linezolid; BDQ: bedaquiline; ERM: erythromycin; DHFR: dihydrofolate reductase; KatG: mycobacterial catalase–peroxidase; InhA: enoyl‐ACP reductase; FAS II: type II fatty acid synthase system; Pzase: pyrazinamidase; PanD: aspartate 1‐decarboxylase; PABA: p‐aminobenzoic acid; DHF: dihydrofolate; THF: tetrahydrofolate; NADH: nicotinamide adenine dinucleotide; L‐ASP: L‐aspartic acid; β‐Ala: β‐alanine; CoA: co‐enzyme A; ATP: adenosine triphosphate. Created with Biorender.com.