FIGURE 1.

The seven human neurofilament isoforms. Structure models of the Nf isoforms are shown as a protein cartoon. The α‐helical domains are structured and contain a highly conserved rod domain common to all Nf isoforms. Expression is restricted to the CNS for INA (in yellow) and to the PNS for PRPH (in magenda). The remaining isoforms NfH (in blue), NfM (in green) and NfL (in red) are not specific for one single nervous system. NfL, NfM and NfH are expressed both in the CNS and PNS. Currently available immunoassays quantify NfL, NfH or NfM.