TABLE A1.
List of excluded DPYD‐genotype studies.
| First author, year published (PMID if available) | n (total) | DPYD*2A | DPYD*13 | D949V | HapB3 | Homo/compound | Total patients with clinical DPYD‐variants | Test all 4 variants |
|---|---|---|---|---|---|---|---|---|
| Amstutz 2015 (26804235) Excluded due to data overlap with Froehlich et al. (24923815) | 514 | 7 | 2 | 3 | 23 | 2 | 37 | yes |
| Lee 2020 (Abstract only) (Asia‐Pacific Journal of Clinical Oncology / 2020;16(SUPPL 8):172 Netherlands Blackwell Publishing Ltd 2020 /) | 176 | Tested no data | Tested no data | Tested no data | Tested no data | 0 | 0 | yes |
| Meulendijks 2017(28427087) (Included in the phenotype part of the review) | 550 | Tested before. Excluded | 3 | 6 | 22 | 0 | 31 | No |
| Thomas 2011(22045187) | 131 | 0 | Not tested | Not tested | Not tested | 0 | 0 | No |
| Deng 2020 (33280607) | 104 | 0 | Not tested | Not tested | Not tested | 0 | 0 | No |
| Etienne‐Grimaldi 2010 (20078613) | 117 | 0 | Not tested | Not tested | Not tested | 0 | 0 | No |
| Kit 2020 (Abstract only) (Journal of Clinical Oncology / 2020;38(4 Supplement): Netherlands American Society of Clinical Oncology 2020) | 104 | 0 | 0 | 0 | Not tested | 0 | 0 | No |
| Joerger 2015 (25677447) | 140 | 1 | Not tested | 3 | Not tested | 0 | 4 | No |
| Rosmarin 2015(24647007) | 1.046 | 1 | 1 | 2 | Not tested | 0 | 4 | No |
| Amstutz 2009 (19530960) | 111 | 1 | 1 | Not tested | Not tested | 0 | 2 | No |
| Borro 2017 (27738344) | 107 | 1 | Not tested | Not tested | Not tested | 0 | 1 | No |
| Onesti 2017 (27845948) | 126 | 1 | Not tested | Not tested | Not tested | 0 | 1 | No |
| Roberto 2017 (27864592) | 142 | 1 | Not tested | Not tested | Not tested | 0 | 1 | No |
| Largillier 2006 (17000685) | 105 | 1 | Not tested | Not tested | Not tested | 0 | 1 | No |
| Ribelles 2008 (18473752) | 136 | 1 | Not tested | Not tested | Not tested | 0 | 1 | No |
| Sulzyc‐Bielicka 2008 (18443386) | 252 | 1 | Not tested | Not tested | Not tested | 0 | 1 | No |
| Puerta‐García 2020 (33035787) | 194 | 1 | 0 | 0 | Not tested | 0 | 1 | No |
| Vivaldi 2021 (33462346) | 104 | 1 | 0 | 0 | Not tested | 0 | 1 | No |
| Boisdron‐Celle 2007 (17064846) | 252 | 2 | Not tested | 7 | Not tested | 1 | 10 | No |
| Milano 2016 (27454530) | 243 | 2 | Not tested | 2 | Not tested | 0 | 4 | No |
| Kristensen 2010 (20819423) | 122 | 2 | Not tested | 1 | Not tested | 0 | 3 | No |
| Boige 20103 (20385995) | 346 | 2 | Not tested | Not tested | Not tested | 0 | 2 | No |
| AlvaradoFernandez 2021 (Abstract only) (European Journal of Hospital Pharmacy 2021;28(SUPPL 1):A132 Netherlands BMJ Publishing Group 202) | 171 | 3 | Not tested | 3 | Not tested | 0 | 6 | No |
| Chi 2020 (Abstract only) (DOI: 10.1200/JCO.2020.38.15_suppl.e16138 Journal of Clinical Oncology 38, no. 15_suppl) | 226 | 3 | Not tested | 1 | Not tested | 0 | 4 | No |
| Loganayagam 2013 (23736036) | 430 | 4 | 1 | 5 | Not tested | 0 | 10 | No |
| Magnani 2013 (23585145) | 180 | 4 | Not tested | Not tested | Not tested | 0 | 4 | No |
| Burnett 2020 (Abstract only) (doi.org/10.1016/j.annonc.2020.04.268) | 506 | 5 | Not tested | 5 | Not tested | 0 | 10 | No |
| Cremolini 2018 (29487697) | 443 | 5 | 0 | 5 | Not tested | 0 | 10 | No |
| Kleibl 2009 (19473056) | 124 | 5 | Not tested | Not tested | 4 | 0 | 9 | No |
| Gross 2008 (19104657) | 181 | 5 | Not tested | 1 | (1) | 0 | 7 | No |
| Botticelli 2017 (28296649) | 642 | 6 | Not tested | Not tested | Not tested | 0 | 6 | No |
| Nahid 2018 (29134491) | 161 | 8 | Not tested | Not tested | Not tested | 0 | 8 | No |
| Morel 2006 (17121937) | 487 | 9 | 1 | 10 | Not tested | 1 | 21 | No |
| Schwab 2008 (18299612) | 683 | 13 | Not tested | 5 | 1 | 0 | 13 | No |
| Deligonul 2021 (33877893) | 100 | 15 | Not tested | Not tested | Not tested | 0 | 15 | No |
| Deenen 2016 (26573078) | 2.038 | 22 | Not tested | Not tested | Not tested | Not tested | 22 | No |
| Jolivet 2021 (33274825) | 2.617 | 24 | Not tested | Not tested | Not tested | 1 | 25 | No |
| Lee 2014 (25381393) | 2.886 | 27 | 4 | 32 | Not tested | 0 | 63 | No |
| Iachetta 2019 (30858516) | 1.827 | 31 | 2 (668) | 5 (668) | Not tested | 0 | 38 | No |
| Henricks 2019 (30485432) | 1.646 | 40 | Not tested | Not tested | Not tested | 0 | 40 | No |
| Toffoli 2015 (26099996) | 603 | 11 (603) | 1 (595) | 5 (588) | Not tested | 1 | 17 | No |
| Madi 2018 (30114658) | 2.183 | 23 (2105) | Not tested | 30 (2116) | Not tested | 0 | 53 | No |
| Graham 2020 (Abstract only) (Journal of Clinical Oncology / 2020;38(4 Supplement): Netherlands American Society of Clinical Oncology 2020 /) | 201 | No Specific data | No Specific data | No Specific data | No Specific data | 0 | 0 | No |
| Kanai 2020 (Abstract only) (Annals of Oncology / 2020;31(Supplement 6):S1359 Netherlands Elsevier Ltd 2020 /) | 3135 | No Specific data | No Specific data | No Specific data | No Specific data | 0 | 0 | No |
| Lee 2016 (26658227) | 1.953 | Not tested | Not tested | Not tested | 78 | 0 | 78 | No |
| Meulendijks 2017 (27995989) | 185 | Not tested | Not tested | 3 | 5 | 0 | 8 | No |
| Pare 2010 (20653680) | 234 | Not tested | Not tested | Not tested | Not tested | 0 | 0 | No |
| Zhang 2012 (22490566) | 362 | Not tested | Not tested | Not tested | Not tested | 0 | 0 | No |
| Yokoi 2020 (32619063) | 301 | Not tested | Not tested | Not tested | Not tested | 0 | 0 | No |
| Murphy 2020 (Abstract only) (Journal of Clinical Oncology / 2020;38(15): Netherlands American Society of Clinical Oncology 2020 /) | 742 | Not tested | Not tested | Not tested | Not tested | 0 | 0 | No |
| Personeni 2020 (Abstract only) (Tumori / 2020 ;106(2 SUPPL):181‐182 Netherlands SAGE Publications Ltd 2020 /) | 179 | Not tested | Not tested | Not tested | Not tested | 0 | 0 | No |
| Cortejoso 2014 (25137161) | 157 | Not tested | Not tested | Not tested | Not tested | 0 | 0 | No |
| Celik 2002 (12025228) | 200 | Not tested | Not tested | Not tested | Not tested | 0 | 0 | No |
| Fidlerova 2010 (19649633) | 113 | Not tested | Not tested | Not tested | Not tested | 0 | 0 | No |
| Pellicer 2017 (28347776) | 301 | Not tested | Not tested | Not tested | Not tested | 0 | 0 | No |
| Zhao 2016 (26846104) | 249 | Not tested | Not tested | Not tested | Not tested | 0 | 0 | No |
| Varma 2019 (31653159) | 234 | Not tested | Not tested | Not tested | Not tested | 0 | 0 | No |
[Correction added on 26 September 2022, after first online publication: PMID numbers have been added to Table A1.]