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. 2022 Sep 23;20(11):2666–2678. doi: 10.1111/jth.15864

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© 2022 The Authors. Journal of Thrombosis and Haemostasis published by Wiley Periodicals LLC on behalf of International Society on Thrombosis and Haemostasis.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Aggregation, secretion, and αIIbβ3 activation induced by thrombin. A, B, Aggregation of washed Flna ^loxP PF4‐Cre ⁻ (Ctrl) and Flna ^loxP PF4‐Cre ⁺ platelets was induced by thrombin (30, 40, and 80 mU/ml). C, Dense granule secretion measured after 3 min of platelet aggregation was quantified by measuring adenosine triphosphate release. D, E, Quantification of P‐selectin exposure and αIIbβ3 activation in conditions of unstirred platelets was assessed by flow cytometry using an anti‐P‐selectin antibody and the JON/A monoclonal antibody specific for the activated form of αIIbβ3. The graph represents the means ± standard error of the mean of three independent determinations. *p < .05, ***p < .001 (one‐way analysis of variance with Sidak's post hoc test for multiple comparisons)