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. 2023 Jan 7;20:7. doi: 10.1186/s12974-022-02686-6

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Cuprizone (CPZ) mediated demyelination and teriflunomide treatment. A Rostro-caudal directed coronal brain slices were collected between − 1.94 and − 2.34 mm Bregma. B Timeline of (C–C′′) CPZ induced demyelination and of teriflunomide treatment in adult (8 weeks) mice. CPZ treatment lasted for 6 weeks. Teriflunomide was applied orally by means of two different application schemes: (1) early pulse during the fourth week of cuprizone challenge for 7 consecutive days (pulse) or (2) continuously for the final 20 days of cuprizone treatment (constant). Mice were sacrificed after 7 days of remyelination