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. 2023 Jan 7;23:4. doi: 10.1186/s12876-022-02621-2

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 9 — The CAF-associated SPOCK1, POSTN, CD68, and CD206 expression in clinical samples of Colon cancer and Para-Colon cancer. A Positive correlation of CD68 and CD206 with SPOCK1and POSTN expression in human colon cancer tissues downloaded from TIMER. B Representative tissue IHC results for SPOCK1, POSTN, CD68, and CD206. Scale bar = 50 μm. C Mean optical density for SPOCK1, POSTN, CD68, and CD206, respectively. D Representative tissue immunofluorescence images for SPOCK1, POSTN, CD68, and CD206. Scale bar = 50 μm. E Mean fluorescence intensity for SPOCK1, POSTN, CD68, and CD206, respectively. *p < 0.05; **p < 0.01; ***p < 0.001