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In Vivo Pharmacokinetic Parameters of 111 in Female CD-1 Mice (n = 3, Mean ± SD)
| pharmacokinetic indices | analogue 111 |
|---|---|
| dose i.v., p.o. (mg/kg) | 0.5, 10 |
| AUC0–24h (i.v., h·ng/mL) | (4.20 × 103) ± 308 |
| Vd (i.v., mL/kg) | 322 ± 24 |
| CL (i.v., mL/(kg·h)) | 119 ± 9.2 |
| t1/2 (i.v., h) | 1.88 ± 0.08 |
| AUC0–24h (p.o., h·ng/mL) | (4.33 × 104) ± 543 |
| Cmax (p.o., ng/mL) | (3.10 × 103) ± 780 |
| F (%) | 51.6 ± 5.2 |
