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. Author manuscript; available in PMC: 2023 Oct 27.
Published in final edited form as: J Med Chem. 2022 Oct 11;65(20):13910–13934. doi: 10.1021/acs.jmedchem.2c01151

Table 12.

Serum Effects on MRSA MIC of Lead 4-Aminoquinoline and 5-Amino-4-quinolone Compounds

compd MIC (μg/mL) MIC + 10% FBS (μg/mL) MIC + 10% mouse serum (μg/mL)
22 0.0625 8
31 0.25 4–8
111 <0.0625 4 4–8
120 0.125 4