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C-2 and C-4 Substituted Quinolines
|
||||
|---|---|---|---|---|
| compd | R1 | R2 | MIC (μg/mL) | clog P |
| 105 | piperazinyl | 5-(trifluoromethyl) pyridin-2-yl-amino | 0.5–1 | 5.1 |
| 106 | 5-(trifluoromethyl) pyridin-2-yl-amino | piperazinyl | 4–8 | 5.1 |
| 107 | morpholino | 5-(trifluoromethyl) pyridin-2-yl-amino | >32 | 5.1 |
| 108 | 5-(trifluoromethyl) pyridin-2-yl-amino | morpholino | 8 | 5.1 |
