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. Author manuscript; available in PMC: 2023 Oct 27.
Published in final edited form as: J Med Chem. 2022 Oct 11;65(20):13910–13934. doi: 10.1021/acs.jmedchem.2c01151

Table 8.

5- and 7-Substituted Quinolinones

graphic file with name nihms-1861478-t0010.jpg
compound R1 R2 MIC (μg/mL) clog P
111 CF3 5-(trifluoromethyl)pyridin-2-yl-amino <0.0625 3.8
112 CF3 3,4-dichloroanilino <0.0625 5.2
113 CF3 3,4-difluoroanilino <0.0625 4.1
114 CF3 5-(fluoro)pyridin-2-yl-amino 0.125 3.1
115 CF3 6-(trifluoromethyl)pyridazine-3-yl-amino 1 2.9
116 CF3 5-dimethylaminopyridin-2-yl-amino 2 3.6
117 CF3 (N,N-dimethyl-6-sulfamoyl) pyridin-2-yl-amino 2 2.1
118 CF3 1H-indazol-4-yl-amino 2 3.6
119 CF3 morpholino >32 2.1
120 CF3 4-(trifluoromethyl)cyclohexyl-amino 0.125 3.9
122 F 5-(trifluoromethyl)pyridin-2-yl-amino 1 3.1