Table 1.
Characteristics of the studies included in this systematic review
| First author, year | Studied Genes (polymorphisms) | Primary outcome |
|---|---|---|
| Matthias, 1998 [8] | CCND1 (A870G) | DFS |
| Holley, 2001 [9] | CCND1 (A870G, G1722C) | DFS |
| Sullivan, 2004 [10] | p53 (Arg72Pro) | OS, PFS |
| Wang, 2004 [11] | DNMT3B6 (C-149T) | OS |
| Streit, 2004 [12] | FGFR4 (Gly388Arg) | OS |
| Monteiro, 2004 [13] | CCND1 (A870G) | OS, DFS |
| Geisler, 2005 [14] | GSTT1 (deletion), GSTM1 (deletion), GSTP1 (Ile105Val), XRCC1 (Arg399Gln, Arg194Trp) | OS, DSS |
| Etienne-Grimaldi, 2005 [15] | EGFR (rs11568315) | DSS |
| Gal, 2005 [16] | XRCC1 (Arg399Gln), XRCC3 (Thr241Met), XPD (Lys751Gln), MGMT (Leu84Phe), MGMT (Val143Ile) | OS, DSS |
| Kondo, 2005 [17] | MMP1 (1G 1607 2G) | OS |
| Wong, 2006 [18] | CTLA-4 (A49G) | OS |
| Carles, 2006 [19] | XPA (rs1800975), XPC (Lys939Gln), XPD (Lys751Gln), ERCC1 (Lys259Thr), ERCC5 (His1104Asp, C581T), XRCC5 (rs1051677, rs1051685), XRCC1 (Arg399Gln) | OS |
| Matthias, 2006 [20] | CCND1 (A870G), TNFa (TNFBID5) | DFS |
| Quintela-Fandino, 2006 [21] | ERCC1 (C8092A), XPD (Asp312Asn, Lys751Gln), XRCC1 (Arg399Gln) | OS |
| da Costa Andrade, 2007 [22] | FGFR4 (Gly388Arg) | OS |
| Lehnerdt, 2009 [23] | BCL2 (−938C>A) | DFS, OS |
| Lundberg, 2009 [24] | TGFβ1 (rs1982073) | DFS, OS |
| Klinghammer, 2010 [25] | EGFR (R521K, CA-SSR) | PFS, OS |
| Lundberg, 2010 [26] | TGFβ1 (rs1982073) | DFS, OS |
| Tanuma, 2010 [27] | FGFR4 (Gly388Arg), TP53 (Mutant) | OS |
| Corrêa, 2011 [28] | TNF-α (−308) | OS |
| Bergmann, 2011 [29] | TLR4 (Asp299Gly, Thr399Ile) | DFS, OS |
| De Castro, 2011 [30] | ERCC1 (T19007C) | OS |
| Hama, 2011 [31] | VDR (rs11568820), FokI (rs10735810), BsmI (rs1544410), ApaI (rs7976091), TaqI (rs731236) | PFS |
| Zhong, 2011 [32] | ERCC2 (rs13181), CCND1 (rs9344) | OS, DSS, PFS, DFS |
| Wang, 2012 [33] | KRAS (rs1137282, rs712) | OS |
| Azad, 2012 [34] | CCND1 (A870G), TP53 (Arg72Pro), DNMT3B (C149T), ERCC1 (C8092A, Lys259Thr), ERCC4 (T2505C), ERCC5 (C581T, His1104Asp), MSH2 (C211þ9G), ERCC2 (Asp312Asn, Lys751Gln), XRCC1 (Arg399Gln), XRCC3 (Thr241Met), FGFR4 (Gly388Arg), CTLA4 (A49G), MMP3 (−1612insA), GSTM1 (Deletion), GSTT1 (Deletion), CYP2D6 (*3, *4, *5) | OS, DFS |
| Lima, 2012 [35] | ERCC1 (G19007A) | OS |
| Lundberg, 2012 [36] | TGFβ1 (rs1800470) | OS, DFS |
| Stoehlmacher-Williams, 2012 [37] | EGFR (−216 G/T, −191 C/A, R497K G → A), EGF (61 A/G) | OS |
| Supic, 2012 [38] | VEGF-A (−2578C/A, −1154A/G, −634G/C, +936C/T) | OS |
| Liu, 2013 [39] | FGFR4 (rs351855), VEGF (rs2010963, rs833061, rs3025039), ERCC1 (rs3212986), ERCC2 (rs1799793, rs13181 ), XRCC1 (rs25487), hOGG1 (rs1052133), APEX1 (rs1130409), ADPRT (rs1136410), MTHFR (rs1801131, rs1801133), ABCB1 (rs1045642, rs2032582), MPO (rs2243828), MDM2 (rs2279744) | OS, PFS |
| Guan, 2013 [40] | Pre-microRNA (rs2910164, rs2292832, rs11614913, rs3746444) | OS, DSS, DFS |
| Jin, 2013 [41] | IL-10 (rs1800871, rs1800872, rs1800896) | OS, DSS, DFS |
| Liu, 2013 [42] | miR-196a2 (rs11614913) | DFS |
| Zhang, 2014 [43] | TNF-α (rs1800629, rs1799724, rs1800630, rs1799964) | DFS |
| Chung, 2014 [44] | KRAS (rs61764370) | OS, PFS |
| Lin, 2014 [45] | hMLH1 (rs1800734, rs1540354) | OS, DFS |
| Su, 2014 [46] | EGF (A61G A>G), EGFR (R521K G>A, G-216T) | OS, PFS |
| Zhang, 2014 [47] | TNF-α (rs1800629, rs1799724, rs1800630, rs1799964) | DFS |
| Farnebo, 2015 [48] | XPC (A499V), XPD (K751Q), XRCC1 (R399Q), XRCC3 (T241M) | OS |
| Pfisterer, 2015 [49] | AKT1 (rs2494738, rs2498804, rs3803304), AKT2 (rs892119, rs8100018), FRAP1 (rs11121704, rs2295080), PIK3CA (rs2699887, rs7640662), PTEN (rs12569998, rs2299939) | OS, PFS |
| Reuter, 2015 [50] | PXR (rs3814055, rs1523127, rs2472677, rs6785049, rs2276707, rs1054190, rs1054191) | OS |
| Stur, 2015 [51] | XRCC1 (Arg194Trp, Arg399Gln), XRCC3 (Thr241Met), XPC (Lys939Gln), ERCC1 (Asn118Asn), RAD51 (−98G>C) | DSS, DFS |
| Costa, 2016 [52] | OGG1 (rs1052133), APEX1 (rs1130409), XRCC1 (rs3213245, rs1799782, rs25489, rs25487) | PFS, OS |
| Wang, 2016 [53] | Pre-microRNA (rs2910164, rs11614913, rs2292832, rs3746444) | OS, DSS, DFS |
| Agostini, 2017 [54] | ATM (5557G>A, IVS62 + 60G>A), TP53 (215G>C), BCL2 (−938C>A), TGFβ (−509C>T, 29C>T) | DFS, DSS |
| Braig, 2017 [55] | EGFR (EGFR-K521) | PFS |
| Chen, 2017 [6] | FADS1 (rs174549) | PFS, OS |
| Lopes-Aguiar, 2017 [56] | XPC (c.2815A>C), XPD (c.934G>A, c.2251A>C), XPF (c.2505T>C), ERCC1 (c.354C>T) | PFS, OS |
| Zhu, 2017 [57] | ATM (rs227091), BRCA1 (rs12516, rs8176318), PARP1 (rs8679), LIG3 (rs4796030), NBS1 (rs2735383, rs1063054, rs1063053), RAD51 (rs7180135) | DFS |
| Magnes, 2018 [58] | FCGR2A (rs1801274), FCGR3A (rs396991) | PFS, OS |
| Nanda, 2018 [7] | XRCC1 (Arg194Trp) | DFS, OS |
| Senghore, 2019 [59] | MSH2 (rs3732183), MSH3 (rs12515548, rs26279), EXO1 (rs1047840), MLH1 (rs1800734) | DFS, OS |
| Senghore, 2019 [60] | ERCC5 (rs2094258, rs1047768, rs17655, rs873601), ERCC2 (rs13181, rs1799793), ERCC1 (rs735482, rs3212986, rs11615), XPC (rs2228001, rs2228000), XPA (rs1800975, rs10817938) | OS, DFS |
| Hirakawa, 2020 [4] | ERCC1 (C8092A), XRCC1 (Arg399Gln) | OS |
| Butkiewicz, 2020 [61] | VEGF (rs2010963, rs699947, rs3025039), VEGFR1 (rs9582036, rs7996030), VEGFR2 (rs2071559, rs1870377), ANGPT1 (rs2507800, rs1954727), ANGPT2 (rs3739391, rs3020221), TEK (rs639225) | OS, DFS |
| Dutta, 2020 [62] | XRCC1 (Arg399Gln) | OS, PFS |
| Maniglia, 2020 [63] | GSTT1 (Deletion), GSTM1 (Deletion), GSTP1 (A313G, C341T) | OS |
| Senghore, 2020 [64] | XRCC1 (rs25487, rs25489, rs1799782), OGG1 (rs1052133), APEX1 (rs1760944), MUTYH (rs3219489) | OS, DFS |
| Yadav, 2021 [65] | CYP2A6 (*4B, *4C, *9) | OS |
| Dimitrakopoulos, 2021 [66] | VEGFA (rs699947, rs12664104, rs34376996, rs144854329, rs35864111, rs833061, rs149983590, rs833062, rs1570360, rs28357093, rs13207351, rs79469752, rs59260042, rs3025039, rs149179279, rs112005313, rs187429037, rs111933757), EDNRA (rs5333, rs5334, rs10305924, rs17856670, rs112710542), FAS (rs1800682, rs34995925, rs2234768, rs150130637), NBS1 (rs1805794, rs192240705, rs780661058, rs151070415, rs61754966, rs182756889) | OS |
| Guberina, 2021 [67] | ERCC2 (rs1799793, rs13181, rs50871), XRCC6 (rs2267437), ERCC1 (rs11615), ATM (rs4988023), ERCC5 (rs17655), XRCC1 (rs25487) | OS, DFS |
| Duran, 2021 [68] | ABCB1 (rs1045642, rs2032582), ABCC1 (rs246221, rs45511401), ABCC2 (rs717620), ABCG2 (rs2231142), ATP6V1C1 (rs2248718), ATP7B (rs1061472, rs1801244, rs2147363), CDA (rs2072671), ND3 (rs2853826), RRM1 (rs12806698), SLC28A1 (rs2242047), COX-2 (rs689466), IL3 (rs1800925), TGFB1 (rs1800469), FGFR4 (rs351855), GSTP1 (rs1695), NQO1 (rs1800566), MMP-2 (rs12934241), SOD2 (rs4880), RAD51 (rs1801320), XRCC6 (rs2267437), ERCC1 (rs11615, rs3212986), ERCC4 (rs1799801), XPC (rs2228001), ERCC2 (rs13181, rs1799793, rs238406), ERCC5 (rs17655), XRCC1 (rs25487), XRCC2 (rs6464268), XRCC3 (rs861539), RPA34 (rs735482) | OS, DFS |
| Jović, 2021 [69] | CCND1 (rs9344), p21 (rs1801270, rs1059234) | OS, DFS |
| Lubiński, 2021 [70] | SOD2 (rs4880), CAT (rs1001179), GPX1 (rs1050450) | OS |
| Novais, 2021 [71] | XRCC1 (rs25487), HOGG1 (rs1052133), CYP1A1 (rs1048943), GSTM1 (rs4025935), GSTT1 (rs71748309), GSTP1 (rs1695), NAT2 (*4) | OS, DFS |
| Pasvenskaite, 2021 [72] | IL-10 (rs1800871, rs1800872, rs1800896) | OS |
| Pasvenskaite, 2021 [73] | IL-9 (rs1859430, rs2069870, rs11741137, rs2069885, rs2069884) | OS |
| Wei, 2021 [74] | ERCC2 (rs13181) | OS, DFS |
| Zhu, 2021 [75] | UCA1 (rs7255437) | DSS |
OS — overall survival; PFS — progression-free survival; DFS — disease-free survival; DSS — disease-specific survival