FIG. 8.

Inhibition of staphylococcus-platelet binding by rClfA. Strains ISP479C and PS12 were added to immobilized platelet monolayers pretreated with 0 to 50 μg of rClfA per ml. Binding is expressed as a percentage of the inoculum (mean ± standard deviation). ISP479C binding to platelets was significantly reduced at all rClfA concentrations tested compared with untreated platelets (0 μg/ml) (∗, P = 0.05; ∗∗, P = 0.02; ∗∗∗, P < 0.0001) (n = 6). Note that at 50 μg/ml of rClfA, binding of ISP479C is reduced to that of PS12.