Table 1.
Ribosome-related factors and CVD
| Factors | Types | Targets | Function | Ref. |
|---|---|---|---|---|
| rDNA | Cardiomyocyte | p-UBF↑ | Promotes cardiac hypertrophy | 201–204 |
| Cardiomyocyte | Ncl↑ | Inhibits myocardial infarction | 235–237 | |
| Cardiomyocyte | Ncl↑ | Promotes cardiomyocyte differentiation | 166,169,170 | |
| rRNA | Cardiomyocyte | S6K1↑ | Promotes cardiac hypertrophy | 161 |
| Cardiomyocyte | RNA Pol I↑ | Promotes cardiac hypertrophy | 160 | |
| Cardiomyocyte | rDNA↑ | Promotes cardiac hypertrophy | 151,161 | |
| RP | Cardiomyocyte | RPL9/26↓ | Promotes myocardial infarction | 168 |
| Macrophages | RPL13↑ | Inhibits atherosclerosis | 181–183 | |
| Blood cells | RPL9/23/35, RPS7↓ | Promotes atherosclerosis | 184 |