Fig. 3.

The effect of MMP-408 on recovery from liver injury and fibrosis. Panel A: The effect of MMP-408 on hepatic AST (left) and Col1a1 mRNA expression (middle) and Lox (right) during recovery were determined. Panel B: The effect of MMP-408 on resolution of fibrosis was assessed by Sirius Red staining (100 × ). Panel C: Intensity of Sirius red staining was assessed by image analysis (left). The hepatic content of desmosine was determined by ELISA (right). Quantitative data are reported as box and whisker plots, which show the median (thick line), interquartile range (box) and range (whiskers) (n = 4–6). ^aP < 0.05 compared with absence of CCl₄; ^bP < 0.05 compared with vehicle group by repeated measures 2-way ANOVA using Bonferroni’s post hoc test. Calibration bars for the photomicrographs are 80 µm. Groups surrounded by a box all are significantly different than control. (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.)