Table 3.
Physicochemical characteristics of the printlets (PRT) and mini-printlets (MPRT) prepared with different DEX forms: dexamethasone free acid (DEX), dexamethasone acetate (DEX-A) and dexamethasone sodium phosphate (DEX-P). Results are expressed as mean ± SD.
| Formulation | Mean weight (g) | Diameter (mm) | Height (mm) | Drug content (mg/unit) | Drug loading (%) |
|---|---|---|---|---|---|
| PRT-DEX | 0.218 ± 0.014 | 8.96 ± 0.20 | 4.07 ± 0.04 | 10.87 ± 0.26 | 5.40 ± 0.21 |
| MPRT-DEX | 0.035 ± 0.002 | 4.40 ± 0.23 | 2.35 ± 0.04 | 1.90 ± 0.09 | 5.22 ± 0.06 |
| PRT-DEX-A | 0.207 ± 0.011 | 8.60 ± 0.22 | 4.20 ± 0.05 | 9.71 ± 0.35 | 4.87 ± 0.03 |
| MPRT-DEX-A | 0.034 ± 0.002 | 4.28 ± 0.12 | 2.41 ± 0.02 | 1.66 ± 0.14 | 4.96 ± 0.26 |
| PRT-DEX-P | 0.206 ± 0.015 | 8.66 ± 0.21 | 3.99 ± 0.05 | 10.83 ± 0.15 | 5.11 ± 0.26 |
| MPRT-DEX-P | 0.032 ± 0.003 | 4.28 ± 0.13 | 2.29 ± 0.05 | 1.83 ± 0.17 | 5.34 ± 0.10 |