Figure 2.

Rapid kinase activity impacts of adavosertib extend beyond CDK1 and CDK2

(A) Relative kinase activities (RKA) of quantifiable CDKs, that have >5 detected phosphorylation sites. The red bar indicates the significance (p = 0.01) boundary. Black bars indicate the SE of the activity score.

(B) Relative kinase activity shifts for CDK1 and CDK2. Black bars indicate the propagated SE of the activity shift.

(C and D) RKA plot showing activity of other affected kinases that were correlated with CDK activity.

(E) Illustration of CK2 subunit CSNK2A1 and CSNK2A2 known CDK-dependent phosphorylation sites.